----------------------------------------------------------------------
Changes included in 2026-01-21.1
----------------------------------------------------------------------

Highlights:
- New beta-lactamase alleles assigned by Institut Pasteur
- Added POINT_DISRUPT genes for Klebsiella_pneumoniae mgrB and ramR
- Added POINT_DISRUPT genes for Pseudomonas_aeruginosa ampD, mexR, mexZ, nalD, nfxB, and oprD and revised subclasses for point mutations in some of them
- New mle node for macrolide esterases and several new mle genes
- Removed crpP which has no effect on phenotype in public AST data and limited evidence for inclusion
- Removed dfrA51 which has no effect on phenotype in public AST data and limited evidence for inclusion

Summary:
   Total proteins: 9633
        Core proteins: 8278
        Plus proteins: 1351
   AMR proteins: 8340
   STRESS proteins: 259
   VIRULENCE proteins: 1034
   PubMed references: 5629
   Point mutations: 1516
   Point mutation reference sequences: 274
   Point mutation organism groups: 
       Acinetobacter_baumannii, Bordetella_pertussis, Burkholderia_cepacia,
       Burkholderia_pseudomallei, Campylobacter, Citrobacter_freundii,
       Clostridioides_difficile, Corynebacterium_diphtheriae, Enterobacter_asburiae,
       Enterobacter_cloacae, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Haemophilus_influenzae, Helicobacter_pylori, Klebsiella_oxytoca,
       Klebsiella_pneumoniae, Neisseria_gonorrhoeae, Neisseria_meningitidis,
       Pseudomonas_aeruginosa, Salmonella, Serratia_marcescens, Staphylococcus_aureus,
       Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae,
       Streptococcus_pyogenes, Vibrio_cholerae, Vibrio_parahaemolyticus,
       Vibrio_vulnificus
   HMMs: 774

Updates since release 2025-12-03.1:
   Proteins added: 169
       Core proteins added: 163
       Plus proteins added: 6
   AMR proteins added: 167
   STRESS proteins added: 2
   Alleles added: 147
   PubMed references added: 40
   PubMed references removed: 10
   Proteins removed: 2
       Core proteins removed: 1
       Plus proteins removed: 1
   Reference Gene Catalog entries changed: 67
   Hierarchy nodes added: 17
   Hierarchy nodes removed: 2
   Hierarchy nodes changed: 10

Added proteins
    core AMR AMR
        mleBCA           NG_245857.1 WP_000140039.1     BCA family alpha/beta fold macrolide esterase
        mleBCB           NG_245858.1 WP_459076516.1     BCB family alpha/beta fold macrolide esterase
        mleBRB           NG_245859.1 WP_087344890.1     BRB family alpha/beta fold macrolide esterase
        mleCBF           NG_245860.1 WP_221881166.1     CBF family alpha/beta fold macrolide esterase
        mlePBA           NG_245861.1 WP_459076517.1     PBA family alpha/beta fold macrolide esterase
        mlePBB           NG_245862.1 WP_163953822.1     PBB family alpha/beta fold macrolide esterase
        mrx              NG_245863.1 WP_000004159.1     phosphorylated macrolide efflux MFS transporter Mrx(A)
        blaADC-402       NG_245864.1 WP_031988126.1     extended-spectrum class C beta-lactamase ADC-402
        blaADC-403       NG_245865.1 WP_459076518.1     extended-spectrum class C beta-lactamase ADC-403
        blaCMY-187       NG_245866.1 WP_459076519.1     class C beta-lactamase CMY-187
        blaCMY-225       NG_245867.1 WP_456792573.1     class C beta-lactamase CMY-225
        blaFOX-11        NG_245868.1 WP_459076520.1     cephalosporin-hydrolyzing class C beta-lactamase FOX-11
        blaFOX-22        NG_245869.1 WP_459076521.1     cephalosporin-hydrolyzing class C beta-lactamase FOX-22
        blaGES-70        NG_245870.1 WP_459076522.1     class A beta-lactamase GES-70
        blaIMP-36        NG_245871.1 WP_459076523.1     subclass B1 metallo-beta-lactamase IMP-36
        blaKPC-199       NG_245872.1 WP_459076524.1     inhibitor-resistant class A beta-lactamase KPC-199
        blaKPC-200       NG_245873.1 WP_459076525.1     inhibitor-resistant class A beta-lactamase KPC-200
        blaKPC-285       NG_245874.1 WP_447394154.1     class A beta-lactamase KPC-285
        blaKPC-286       NG_245875.1 WP_459076526.1     carbapenem-hydrolyzing class A beta-lactamase KPC-286
        blaKPC-287       NG_245876.1 WP_459076527.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-287
        blaLEN-29        NG_245877.1 WP_459076528.1     class A beta-lactamase LEN-29
        blaLEN-44        NG_245878.1 WP_459076529.1     class A beta-lactamase LEN-44
        blaLEN-45        NG_245879.1 WP_180254273.1     class A beta-lactamase LEN-45
        blaLEN-46        NG_245880.1 WP_323068966.1     class A beta-lactamase LEN-46
        blaLEN-47        NG_245881.1 WP_459076530.1     class A beta-lactamase LEN-47
        blaLEN-48        NG_245882.1 WP_162677570.1     class A beta-lactamase LEN-48
        blaLEN-49        NG_245883.1 WP_459076531.1     class A beta-lactamase LEN-49
        blaLEN-50        NG_245884.1 WP_373890475.1     class A beta-lactamase LEN-50
        blaLEN-56        NG_245885.1 WP_459076532.1     class A beta-lactamase LEN-56
        blaLEN-57        NG_245886.1 WP_224229311.1     class A beta-lactamase LEN-57
        blaLEN-59        NG_245887.1 WP_459076533.1     class A beta-lactamase LEN-59
        blaLEN-61        NG_245888.1 WP_110203160.1     class A beta-lactamase LEN-61
        blaLEN-62        NG_245889.1 WP_110223294.1     class A beta-lactamase LEN-62
        blaLEN-63        NG_245890.1 WP_117138292.1     class A beta-lactamase LEN-63
        blaLEN-65        NG_245891.1 WP_459076534.1     class A beta-lactamase LEN-65
        blaLEN-66        NG_245892.1 WP_374184211.1     class A beta-lactamase LEN-66
        blaLEN-67        NG_245893.1 WP_373625500.1     class A beta-lactamase LEN-67
        blaLEN-68        NG_245894.1 WP_373632019.1     class A beta-lactamase LEN-68
        blaLEN-69        NG_245895.1 WP_110227413.1     class A beta-lactamase LEN-69
        blaLEN-70        NG_245896.1 WP_242924921.1     class A beta-lactamase LEN-70
        blaLEN-71        NG_245897.1 WP_110203710.1     class A beta-lactamase LEN-71
        blaLEN-72        NG_245898.1 WP_459076535.1     class A beta-lactamase LEN-72
        blaLEN-73        NG_245899.1 WP_459076536.1     class A beta-lactamase LEN-73
        blaLEN-74        NG_245900.1 WP_129765887.1     class A beta-lactamase LEN-74
        blaLEN-75        NG_245901.1 WP_459076537.1     class A beta-lactamase LEN-75
        blaLEN-76        NG_245902.1 WP_373630719.1     class A beta-lactamase LEN-76
        blaLEN-77        NG_245903.1 WP_110217403.1     class A beta-lactamase LEN-77
        blaLEN-78        NG_245904.1 WP_218809187.1     class A beta-lactamase LEN-78
        blaLEN-79        NG_245905.1 WP_080928629.1     class A beta-lactamase LEN-79
        blaLEN-80        NG_245906.1 WP_459076538.1     class A beta-lactamase LEN-80
        blaLEN-81        NG_245907.1 WP_459076539.1     class A beta-lactamase LEN-81
        blaLEN-82        NG_245908.1 WP_459076540.1     class A beta-lactamase LEN-82
        blaLEN-83        NG_245909.1 WP_064170998.1     class A beta-lactamase LEN-83
        blaLEN-84        NG_245910.1 WP_155011402.1     class A beta-lactamase LEN-84
        blaLEN-85        NG_245911.1 WP_426758753.1     class A beta-lactamase LEN-85
        blaLEN-86        NG_245912.1 WP_181481589.1     class A beta-lactamase LEN-86
        blaLEN-87        NG_245913.1 WP_264969628.1     class A beta-lactamase LEN-87
        blaLEN-88        NG_245914.1 WP_374014856.1     class A beta-lactamase LEN-88
        blaLEN-89        NG_245915.1 WP_459076541.1     class A beta-lactamase LEN-89
        blaLEN-90        NG_245916.1 WP_459076542.1     class A beta-lactamase LEN-90
        blaLEN-91        NG_245917.1 WP_459076543.1     class A beta-lactamase LEN-91
        blaLEN-92        NG_245918.1 WP_183476648.1     class A beta-lactamase LEN-92
        blaLEN-93        NG_245919.1 WP_323101933.1     class A beta-lactamase LEN-93
        blaMOX-26        NG_245920.1 WP_459076544.1     CMY-1/MOX family class C beta-lactamase MOX-26
        blaMOX-27        NG_245921.1 WP_459076545.1     CMY-1/MOX family class C beta-lactamase MOX-27
        blaMOX-28        NG_245922.1 WP_459076546.1     CMY-1/MOX family class C beta-lactamase MOX-28
        blaMOX-29        NG_245923.1 WP_459076547.1     CMY-1/MOX family class C beta-lactamase MOX-29
        blaMOX-30        NG_245924.1 WP_459076548.1     CMY-1/MOX family class C beta-lactamase MOX-30
        blaMOX-31        NG_245925.1 WP_459076549.1     CMY-1/MOX family class C beta-lactamase MOX-31
        blaNDM-94        NG_245926.1 WP_459076550.1     subclass B1 metallo-beta-lactamase NDM-94
        blaNDM-95        NG_245927.1 WP_459076551.1     subclass B1 metallo-beta-lactamase NDM-95
        blaNDM-96        NG_245928.1 WP_459076552.1     subclass B1 metallo-beta-lactamase NDM-96
        blaOKP-A-18      NG_245929.1 WP_407299415.1     broad-spectrum class A beta-lactamase OKP-A-18
        blaOKP-A-19      NG_245930.1 WP_102002585.1     broad-spectrum class A beta-lactamase OKP-A-19
        blaOKP-A-20      NG_245931.1 WP_236947656.1     broad-spectrum class A beta-lactamase OKP-A-20
        blaOKP-A-21      NG_245932.1 WP_147733420.1     broad-spectrum class A beta-lactamase OKP-A-21
        blaOKP-A-22      NG_245933.1 WP_101976783.1     broad-spectrum class A beta-lactamase OKP-A-22
        blaOKP-A-24      NG_245934.1 WP_459076553.1     broad-spectrum class A beta-lactamase OKP-A-24
        blaOKP-A-25      NG_245935.1 WP_117132302.1     broad-spectrum class A beta-lactamase OKP-A-25
        blaOKP-A-26      NG_245936.1 WP_459076554.1     broad-spectrum class A beta-lactamase OKP-A-26
        blaOKP-A-27      NG_245937.1 WP_112201582.1     broad-spectrum class A beta-lactamase OKP-A-27
        blaOKP-A-28      NG_245938.1 WP_282279110.1     broad-spectrum class A beta-lactamase OKP-A-28
        blaOKP-A-29      NG_245939.1 WP_459076555.1     broad-spectrum class A beta-lactamase OKP-A-29
        blaOKP-A-30      NG_245940.1 WP_102006432.1     broad-spectrum class A beta-lactamase OKP-A-30
        blaOKP-A-31      NG_245941.1 WP_374026503.1     broad-spectrum class A beta-lactamase OKP-A-31
        blaOKP-A-32      NG_245942.1 WP_180263384.1     broad-spectrum class A beta-lactamase OKP-A-32
        blaOKP-A-33      NG_245943.1 WP_459076556.1     broad-spectrum class A beta-lactamase OKP-A-33
        blaOKP-A-34      NG_245944.1 WP_459076557.1     broad-spectrum class A beta-lactamase OKP-A-34
        blaOKP-A-35      NG_245945.1 WP_459076558.1     broad-spectrum class A beta-lactamase OKP-A-35
        blaOKP-A-36      NG_245946.1 WP_459076559.1     broad-spectrum class A beta-lactamase OKP-A-36
        blaOKP-A-37      NG_245947.1 WP_459076560.1     broad-spectrum class A beta-lactamase OKP-A-37
        blaOKP-A-38      NG_245948.1 WP_459076561.1     broad-spectrum class A beta-lactamase OKP-A-38
        blaOKP-A-61      NG_245949.1 WP_064157593.1     broad-spectrum class A beta-lactamase OKP-A-61
        blaOKP-B-12      NG_245950.1 WP_459076562.1     broad-spectrum class A beta-lactamase OKP-B-12
        blaOKP-B-15      NG_245951.1 WP_117985068.1     broad-spectrum class A beta-lactamase OKP-B-15
        blaOKP-B-25      NG_245952.1 WP_459076563.1     broad-spectrum class A beta-lactamase OKP-B-25
        blaOKP-B-27      NG_245953.1 WP_200982881.1     broad-spectrum class A beta-lactamase OKP-B-27
        blaOKP-B-28      NG_245954.1 WP_264021304.1     broad-spectrum class A beta-lactamase OKP-B-28
        blaOKP-B-29      NG_245955.1 WP_428933462.1     broad-spectrum class A beta-lactamase OKP-B-29
        blaOKP-B-30      NG_245956.1 WP_459076564.1     broad-spectrum class A beta-lactamase OKP-B-30
        blaOKP-B-31      NG_245957.1 WP_285612974.1     broad-spectrum class A beta-lactamase OKP-B-31
        blaOKP-B-32      NG_245958.1 WP_459076565.1     broad-spectrum class A beta-lactamase OKP-B-32
        blaOKP-B-33      NG_245959.1 WP_130938981.1     broad-spectrum class A beta-lactamase OKP-B-33
        blaOKP-B-35      NG_245960.1 WP_459076566.1     broad-spectrum class A beta-lactamase OKP-B-35
        blaOKP-B-37      NG_245961.1 WP_459076567.1     broad-spectrum class A beta-lactamase OKP-B-37
        blaOKP-B-38      NG_245962.1 WP_459076568.1     broad-spectrum class A beta-lactamase OKP-B-38
        blaOKP-B-39      NG_245963.1 WP_459076569.1     broad-spectrum class A beta-lactamase OKP-B-39
        blaOKP-B-42      NG_245964.1 WP_420683110.1     broad-spectrum class A beta-lactamase OKP-B-42
        blaOKP-B-43      NG_245965.1 WP_459076570.1     broad-spectrum class A beta-lactamase OKP-B-43
        blaOKP-B-44      NG_245966.1 WP_459076571.1     broad-spectrum class A beta-lactamase OKP-B-44
        blaOKP-B-46      NG_245967.1 WP_459076572.1     broad-spectrum class A beta-lactamase OKP-B-46
        blaOKP-B-47      NG_245968.1 WP_459076573.1     broad-spectrum class A beta-lactamase OKP-B-47
        blaOKP-B-48      NG_245969.1 WP_410334988.1     broad-spectrum class A beta-lactamase OKP-B-48
        blaOKP-B-49      NG_245970.1 WP_214455971.1     broad-spectrum class A beta-lactamase OKP-B-49
        blaOKP-B-50      NG_245971.1 WP_373856288.1     broad-spectrum class A beta-lactamase OKP-B-50
        blaOKP-B-51      NG_245972.1 WP_106939134.1     broad-spectrum class A beta-lactamase OKP-B-51
        blaOKP-B-52      NG_245973.1 WP_396381039.1     broad-spectrum class A beta-lactamase OKP-B-52
        blaOKP-B-53      NG_245974.1 WP_200928040.1     broad-spectrum class A beta-lactamase OKP-B-53
        blaOKP-B-54      NG_245975.1 WP_109882811.1     broad-spectrum class A beta-lactamase OKP-B-54
        blaOKP-B-55      NG_245976.1 WP_459076574.1     broad-spectrum class A beta-lactamase OKP-B-55
        blaOKP-B-57      NG_245977.1 WP_180241864.1     broad-spectrum class A beta-lactamase OKP-B-57
        blaOKP-B-58      NG_245978.1 WP_459076575.1     broad-spectrum class A beta-lactamase OKP-B-58
        blaOKP-B-60      NG_245979.1 WP_100051170.1     broad-spectrum class A beta-lactamase OKP-B-60
        blaOXA-1209      NG_245980.1 WP_041206632.1     OXA-427 family carbapenem-hydrolyzing class D beta-lactamase OXA-1209
        blaOXA-1210      NG_245981.1 WP_226170892.1     OXA-427 family carbapenem-hydrolyzing class D beta-lactamase OXA-1210
        blaOXA-1420      NG_245982.1 WP_459076576.1     OXA-48 family class D beta-lactamase OXA-1420
        blaOXA-1421      NG_245983.1 WP_459076577.1     OXA-48 family class D beta-lactamase OXA-1421
        blaOXA-1423      NG_245984.1 WP_336041852.1     OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-1423
        blaOXA-1424      NG_245985.1 WP_459076578.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1424
        blaOXA-1425      NG_245986.1 WP_034040414.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1425
        blaOXA-1426      NG_245987.1 WP_459076579.1     OXA-1 family class D beta-lactamase OXA-1426
        blaOXA-1427      NG_245988.1 WP_459076580.1     OXA-10 family class D beta-lactamase OXA-1427
        blaOXA-1431      NG_245989.1 WP_459076581.1     OXA-48 family class D beta-lactamase OXA-1431
        blaOXA-1432      NG_245990.1 WP_459076582.1     OXA-143 family carbapenem-hydrolyzing class D beta-lactamase OXA-1432
        blaPAM-7         NG_245992.1 WP_459076583.1     subclass B3 metallo-beta-lactamase PAM-7
        blaPDC-687       NG_245993.1 WP_459076584.1     class C beta-lactamase PDC-687
        blaPDC-688       NG_245994.1 WP_459076585.1     class C beta-lactamase PDC-688
        blaPDC-689       NG_245995.1 WP_459076586.1     class C beta-lactamase PDC-689
        blaPDC-690       NG_245996.1 WP_459076587.1     class C beta-lactamase PDC-690
        blaPDC-691       NG_245997.1 WP_459076588.1     class C beta-lactamase PDC-691
        blaPDC-692       NG_245998.1 WP_459076589.1     class C beta-lactamase PDC-692
        blaPDC-693       NG_245999.1 WP_459076590.1     class C beta-lactamase PDC-693
        blaPDC-694       NG_246000.1 WP_459076591.1     class C beta-lactamase PDC-694
        blaPDC-695       NG_246001.1 WP_459076592.1     class C beta-lactamase PDC-695
        blaPDC-696       NG_246002.1 WP_459076593.1     class C beta-lactamase PDC-696
        blaPDC-697       NG_246003.1 WP_459076594.1     class C beta-lactamase PDC-697
        blaPDC-698       NG_246004.1 WP_459076595.1     class C beta-lactamase PDC-698
        blaPDC-699       NG_246005.1 WP_459076596.1     class C beta-lactamase PDC-699
        blaPDC-700       NG_246006.1 WP_459076597.1     class C beta-lactamase PDC-700
        blaPDC-701       NG_246007.1 WP_459076598.1     class C beta-lactamase PDC-701
        blaPOM-3         NG_246008.1 WP_459076599.1     subclass B3 metallo-beta-lactamase POM-3
        blaSCO-2         NG_246009.1 WP_414137416.1     class A beta-lactamase SCO-2
        blaSHV-256       NG_246010.1 WP_459076600.1     class A beta-lactamase SHV-256
        blaTLA-4         NG_246011.1 WP_459076601.1     extended-spectrum class A beta-lactamase TLA-4
    core AMR POINT_DISRUPT
        ampD              WP_003112844.1                Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
        mexR              WP_003114897.1                Pseudomonas aeruginosa MarR family transcriptional repressor MexR
        mexZ              WP_003088626.1                Pseudomonas aeruginosa efflux pump transcriptional repressor MexZ
        mgrB              WP_003859906.1                Enterobacter cloacae PhoP/PhoQ regulatory lipoprotein MgrB
        mgrB              WP_002911375.1                Klebsiella pneumoniae PhoP/PhoQ regulatory lipoprotein MgrB
        nalD              WP_003092152.1                Pseudomonas aeruginosa efflux system transcriptional repressor NalD
        nfxB              WP_003094842.1                Pseudomonas aeruginosa efflux pump transcriptional repressor NfxB
        oprD              WP_003112576.1                Pseudomonas aeruginosa outer membrane porin OprD
        ramR              WP_004176968.1                Klebsiella pneumoniae TetR/AcrR family transcriptional regulator RamR
    plus AMR AMR
        mdt               WP_003899060.1                Rv1877 family multidrug efflux MFS transporter
        qseB              WP_001572368.1                QseB-like response regulator transcription factor
        qseC              WP_001572371.1                QseC-like sensor histidine kinase
        rdmCL             WP_000140042.1                spiramycin modification protein RdmCL
    plus STRESS METAL
        ncrA              WP_032676616.1                nickel resistance membrane nickel efflux protein NcrA
        terA              WP_025368659.1                tellurium resistance system protein TerA
Added point mutations
Removed proteins
    core AMR AMR
        dfrA51           NG_242639.1 WP_000781812.1     trimethoprim-resistant dihydrofolate reductase DfrA51
    plus AMR AMR
        crpP              WP_033179079.1                ICE-associated protein CrpP
Changed reference gene catalog records
    cirA AEJ99093.1                                 
        pubmed_reference: <empty> -> 40423723            
    drcA XSG12260.1                                 
        class:           <empty> -> LIPOPEPTIDE         
        subclass:        <empty> -> DAPTOMYCIN          
    drcB XSG12257.1                                 
        class:           <empty> -> LIPOPEPTIDE         
        subclass:        <empty> -> DAPTOMYCIN          
    drcR XSG12259.1                                 
        class:           <empty> -> LIPOPEPTIDE         
        subclass:        <empty> -> DAPTOMYCIN          
    drcS XSG12258.1                                 
        class:           <empty> -> LIPOPEPTIDE         
        subclass:        <empty> -> DAPTOMYCIN          
    ncrA ABF14406.1                                 
        product_name:    Metal Resistance -> nickel resistance membrane nickel efflux protein NcrA 
    ncrA ABF61434.1                                 
        product_name:    Metal Resistance -> nickel resistance membrane nickel efflux protein NcrA 
    ompK35 CAA09665.1                                
        pubmed_reference: <empty> -> 27645385,29621592,17005822 
    ompK36 ADG56549.1                                
        pubmed_reference: <empty> -> 27645385,29621592,40512052 
    ampD_E108Ter WP_003112844.1                                
        product_name:    beta-lactamase expression regulator AmpD -> 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD 
        subclass:        CARBAPENEM -> CEPHALOSPORIN    
    ampD_E67Ter WP_003112844.1                                
        product_name:    beta-lactamase expression regulator AmpD -> 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD 
    ampD_H157Y WP_003112844.1                                
        product_name:    beta-lactamase expression regulator AmpD -> 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD 
    ampD_H36R WP_003112844.1                                
        product_name:    beta-lactamase expression regulator AmpD -> 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD 
    ampD_H77Y WP_003112844.1                                
        product_name:    beta-lactamase expression regulator AmpD -> 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD 
    ampD_Q155Ter WP_003112844.1                                
        product_name:    beta-lactamase expression regulator AmpD -> 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD 
    ampD_Q44Ter WP_003112844.1                                
        product_name:    beta-lactamase expression regulator AmpD -> 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD 
    ampD_S114P WP_003112844.1                                
        product_name:    beta-lactamase expression regulator AmpD -> 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD 
    ampD_T139M WP_003112844.1                                
        product_name:    beta-lactamase expression regulator AmpD -> 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD 
    blaOKP-B-197 MCP6746054.1                                
        gene_family:     blaOKP-B -> blaSHV             
        product_name:    broad-spectrum class A beta-lactamase OKP-B-197 -> chimeric class A beta-lactamase OKP-B/SHV-197 
    blaOXA-1139 UTS94248.1                                
        subclass:        BETA-LACTAM -> CARBAPENEM      
    blaOXA-1182 WAS27906.1                                
        subclass:        BETA-LACTAM -> CARBAPENEM      
    blaOXA-1205 WIF29729.1                                
        product_name:    OXA-48 family class D beta-lactamase OXA-1205 -> OXA-48 family carbapenem-hydrolyzing class D beta-lactamase OXA-1205 
        subclass:        BETA-LACTAM -> CARBAPENEM      
    blaOXA-1207 WJL30769.1                                
        product_name:    OXA-48 family class D beta-lactamase OXA-1207 -> OXA-48 family carbapenem-hydrolyzing class D beta-lactamase OXA-1207 
        subclass:        BETA-LACTAM -> CARBAPENEM      
    blaOXA-1330 XLQ31175.1                                
        subclass:        BETA-LACTAM -> CARBAPENEM      
    blaOXA-1373 XPD12778.1                                
        subclass:        BETA-LACTAM -> CARBAPENEM      
    blaOXA-945 QQY97506.1                                
        subclass:        BETA-LACTAM -> CARBAPENEM      
    mexR_C62Ter WP_003114897.1                                
        product_name:    MarR family transcriptional repressor MexR -> effux pump transcriptional repressor MexR 
    mexR_D89N WP_003114897.1                                
        product_name:    MarR family transcriptional repressor MexR -> effux pump transcriptional repressor MexR 
    mexR_E109Ter WP_003114897.1                                
        product_name:    MarR family transcriptional repressor MexR -> effux pump transcriptional repressor MexR 
    mexR_G101E WP_003114897.1                                
        product_name:    MarR family transcriptional repressor MexR -> effux pump transcriptional repressor MexR 
    mexR_L57P WP_003114897.1                                
        product_name:    MarR family transcriptional repressor MexR -> effux pump transcriptional repressor MexR 
    mexR_L57Q WP_003114897.1                                
        product_name:    MarR family transcriptional repressor MexR -> effux pump transcriptional repressor MexR 
    mexR_Q106Ter WP_003114897.1                                
        product_name:    MarR family transcriptional repressor MexR -> effux pump transcriptional repressor MexR 
    mexR_Q31Ter WP_003114897.1                                
        product_name:    MarR family transcriptional repressor MexR -> effux pump transcriptional repressor MexR 
    mexR_Q49Ter WP_003114897.1                                
        product_name:    MarR family transcriptional repressor MexR -> effux pump transcriptional repressor MexR 
    mexR_Q94Ter WP_003114897.1                                
        product_name:    MarR family transcriptional repressor MexR -> effux pump transcriptional repressor MexR 
    mexR_R70Q WP_003114897.1                                
        product_name:    MarR family transcriptional repressor MexR -> effux pump transcriptional repressor MexR 
    mexR_R83C WP_003114897.1                                
        product_name:    MarR family transcriptional repressor MexR -> effux pump transcriptional repressor MexR 
    mexR_T130P WP_003114897.1                                
        product_name:    MarR family transcriptional repressor MexR -> effux pump transcriptional repressor MexR 
    mexR_Y3Ter WP_003114897.1                                
        product_name:    MarR family transcriptional repressor MexR -> effux pump transcriptional repressor MexR 
    mexZ_E8Ter WP_003088626.1                                
        class:           BETA-LACTAM -> AMINOGLYCOSIDE/BETA-LACTAM/QUINOLONE 
        product_name:    TetR family transcriptional regulator MexZ -> efflux pump transcriptional repressor MexZ 
        pubmed_reference: 37823665 -> 11083635,24145539  
        subclass:        CARBAPENEM -> AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE 
    mexZ_G195E WP_003088626.1                                
        class:           BETA-LACTAM -> AMINOGLYCOSIDE/BETA-LACTAM/QUINOLONE 
        product_name:    TetR family transcriptional regulator MexZ -> efflux pump transcriptional repressor MexZ 
        pubmed_reference: 23045355 -> 11083635,24145539  
        subclass:        CEPHALOSPORIN -> AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE 
    mexZ_G46S WP_003088626.1                                
        class:           BETA-LACTAM -> AMINOGLYCOSIDE/BETA-LACTAM/QUINOLONE 
        product_name:    TetR family transcriptional regulator MexZ -> efflux pump transcriptional repressor MexZ 
        pubmed_reference: 15105137 -> 11083635,15105137,24145539 
        subclass:        CEPHALOSPORIN -> AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE 
    mexZ_Q103Ter WP_003088626.1                                
        class:           BETA-LACTAM -> AMINOGLYCOSIDE/BETA-LACTAM/QUINOLONE 
        product_name:    TetR family transcriptional regulator MexZ -> efflux pump transcriptional repressor MexZ 
        pubmed_reference: 37823665 -> 11083635,24145539  
        subclass:        CARBAPENEM -> AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE 
    mexZ_Q10Ter WP_003088626.1                                
        class:           BETA-LACTAM -> AMINOGLYCOSIDE/BETA-LACTAM/QUINOLONE 
        product_name:    TetR family transcriptional regulator MexZ -> efflux pump transcriptional repressor MexZ 
        pubmed_reference: 15105137 -> 11083635,15105137,24145539 
        subclass:        CEPHALOSPORIN -> AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE 
    mexZ_Q134Ter WP_003088626.1                                
        class:           BETA-LACTAM -> AMINOGLYCOSIDE/BETA-LACTAM/QUINOLONE 
        product_name:    TetR family transcriptional regulator MexZ -> efflux pump transcriptional repressor MexZ 
        pubmed_reference: 37823665 -> 11083635,24145539  
        subclass:        CARBAPENEM -> AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE 
    mexZ_Q69Ter WP_003088626.1                                
        class:           BETA-LACTAM -> AMINOGLYCOSIDE/BETA-LACTAM/QUINOLONE 
        product_name:    TetR family transcriptional regulator MexZ -> efflux pump transcriptional repressor MexZ 
        pubmed_reference: 37823665 -> 11083635,24145539  
        subclass:        CARBAPENEM -> AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE 
    mexZ_Q95Ter WP_003088626.1                                
        class:           BETA-LACTAM -> AMINOGLYCOSIDE/BETA-LACTAM/QUINOLONE 
        product_name:    TetR family transcriptional regulator MexZ -> efflux pump transcriptional repressor MexZ 
        pubmed_reference: 37823665 -> 11083635,24145539  
        subclass:        CARBAPENEM -> AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE 
    mexZ_V43A WP_003088626.1                                
        class:           BETA-LACTAM -> AMINOGLYCOSIDE/BETA-LACTAM/QUINOLONE 
        product_name:    TetR family transcriptional regulator MexZ -> efflux pump transcriptional repressor MexZ 
        pubmed_reference: 15105137 -> 11083635,15105137,24145539 
        subclass:        CEPHALOSPORIN -> AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE 
    mexZ_W167Ter WP_003088626.1                                
        class:           BETA-LACTAM -> AMINOGLYCOSIDE/BETA-LACTAM/QUINOLONE 
        product_name:    TetR family transcriptional regulator MexZ -> efflux pump transcriptional repressor MexZ 
        pubmed_reference: 37823665 -> 11083635,24145539  
        subclass:        CARBAPENEM -> AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE 
    mgrB_A14S WP_002911375.1                                
        product_name:    PhoP/PhoQ regulator MgrB -> PhoP/PhoQ regulatory lipoprotein MgrB 
    mgrB_C28F WP_002911375.1                                
        product_name:    PhoP/PhoQ regulator MgrB -> PhoP/PhoQ regulatory lipoprotein MgrB 
    mgrB_C28Y WP_002911375.1                                
        product_name:    PhoP/PhoQ regulator MgrB -> PhoP/PhoQ regulatory lipoprotein MgrB 
    mgrB_C39Ter WP_002911375.1                                
        product_name:    PhoP/PhoQ regulator MgrB -> PhoP/PhoQ regulatory lipoprotein MgrB 
    mgrB_C39Y WP_002911375.1                                
        product_name:    PhoP/PhoQ regulator MgrB -> PhoP/PhoQ regulatory lipoprotein MgrB 
    mgrB_D31N WP_002911375.1                                
        product_name:    PhoP/PhoQ regulator MgrB -> PhoP/PhoQ regulatory lipoprotein MgrB 
    mgrB_F35I WP_002911375.1                                
        product_name:    PhoP/PhoQ regulator MgrB -> PhoP/PhoQ regulatory lipoprotein MgrB 
    mgrB_G37S WP_002911375.1                                
        product_name:    PhoP/PhoQ regulator MgrB -> PhoP/PhoQ regulatory lipoprotein MgrB 
    mgrB_I45T WP_002911375.1                                
        product_name:    PhoP/PhoQ regulator MgrB -> PhoP/PhoQ regulatory lipoprotein MgrB 
    mgrB_L17R WP_002911375.1                                
        product_name:    PhoP/PhoQ regulator MgrB -> PhoP/PhoQ regulatory lipoprotein MgrB 
    mgrB_L24H WP_002911375.1                                
        product_name:    PhoP/PhoQ regulator MgrB -> PhoP/PhoQ regulatory lipoprotein MgrB 
    mgrB_M27K WP_002911375.1                                
        product_name:    PhoP/PhoQ regulator MgrB -> PhoP/PhoQ regulatory lipoprotein MgrB 
    mgrB_Q30Ter WP_002911375.1                                
        product_name:    PhoP/PhoQ regulator MgrB -> PhoP/PhoQ regulatory lipoprotein MgrB 
    mgrB_V32G WP_002911375.1                                
        product_name:    PhoP/PhoQ regulator MgrB -> PhoP/PhoQ regulatory lipoprotein MgrB 
    mgrB_W20R WP_002911375.1                                
        product_name:    PhoP/PhoQ regulator MgrB -> PhoP/PhoQ regulatory lipoprotein MgrB 
    mgrB_W47R WP_002911375.1                                
        product_name:    PhoP/PhoQ regulator MgrB -> PhoP/PhoQ regulatory lipoprotein MgrB 
    rpoB_P564L WP_000263098.1                                
        subclass:        RIFAMYCIN -> RIFAMPIN/RIFAMYCIN 

Hierarchy nodes Added
    core AMR AMR
        mle              mle NF052610.1                 alpha/beta fold macrolide esterase
        mleBCA           mleBCA                         BCA family alpha/beta fold macrolide esterase
        mleBCB           mleBCB                         BCB family alpha/beta fold macrolide esterase
        mleBRB           mleBRB                         BRB family alpha/beta fold macrolide esterase
        mleCBF           mleCBF                         CBF family alpha/beta fold macrolide esterase
        mlePBA           mlePBA                         PBA family alpha/beta fold macrolide esterase
        mlePBB           mlePBB                         PBB family alpha/beta fold macrolide esterase
        mrx(A)           mrx(A)                         phosphorylated macrolide efflux MFS transporter Mrx(A)
    non-reported AMR AMR
        nalD             nalD                           efflux system transcriptional repressor NalD
        nfxB             nfxB                           efflux pump transcriptional repressor NfxB
        ompK35           ompK35                         outer membrane porin OmpK35
        ompK36           ompK36                         outer membrane porin OmpK36
    plus AMR AMR
        Rv1877           mdt                            Rv1877 family multidrug efflux MFS transporter
        qseB_rel         qseB                           QseB-like response regulator transcription factor
        qseC_rel         qseC                           QseC-like sensor histidine kinase
        rdmCL            rdmCL                          spiramycin modification protein RdmCL
    plus STRESS METAL
        terA             terA                           tellurium resistance system protein TerA
Hierarchy nodes Removed
    core AMR AMR
        dfrA51           dfrA51 NF047324.1              trimethoprim-resistant dihydrofolate reductase DfrA51
    plus AMR AMR
        crpP             crpP                           ICE-associated protein CrpP
Changed Hierarchy Nodes
    blaOKP-A         OKP-A family broad-spectrum class A beta-lactamase 
        hmm_acc:         <empty> -> NF052571.1          
    blaOXA-143_fam   OXA-143 family carbapenem-hydrolyzing class D beta-lactamase 
        subclass:        BETA-LACTAM -> CARBAPENEM      
    blaOXA-20_fam    OXA-20 family oxacillin-hydrolyzing class D beta-lactamase 
        display_parent:  0 -> 1                         
    drcA             daptomycin efflux ABC transporter ATP-binding protein DrcA 
        class:           <empty> -> LIPOPEPTIDE         
        subclass:        <empty> -> DAPTOMYCIN          
    drcB             daptomycin efflux ABC transporter permease DrcB 
        class:           <empty> -> LIPOPEPTIDE         
        subclass:        <empty> -> DAPTOMYCIN          
    drcR             daptomycin efflux response regulator transcription factor DrcR 
        class:           <empty> -> LIPOPEPTIDE         
        subclass:        <empty> -> DAPTOMYCIN          
    drcS             daptomycin efflux sensor histidine kinase DrcS 
        class:           <empty> -> LIPOPEPTIDE         
        subclass:        <empty> -> DAPTOMYCIN          
    estT             macrolide hydrolase EstT       
        parent_node_id:  AMR -> mle                     
    estX             macrolide esterase EstX        
        display_parent:  0 -> 1                         
        parent_node_id:  AMR -> mle                     
    ncrA             nickel resistance membrane nickel efflux protein NcrA 
        name:            Metal Resistance -> nickel resistance membrane nickel efflux protein NcrA 
