----------------------------------------------------------------------
Changes included in 2026-03-24.1
----------------------------------------------------------------------
Overview: 
- POINT_DISRUPT genes curated for Eschericha acrR, cirA, marR, nfsA, nfsB,
  ompC, ompF, uhpT
- New POINT_DISRUPT genes for Klebsiella_pneumoniae and Salmonella
- Point mutations in rpoB for new organism Staphylococcus epidermidis
- blaACT-9 was determined to be a truncated version of blaACT-143, so it was
  removed
- tet(38) moved to the 'plus' category because of evidence of no phenotype in
  normal circumstances
- Cleanup of the ReferenceGeneHierarchy.txt file to remove some accidentally
  published nodes
- New alleles, genes, and point mutations from submissions and literature

Summary:
   Total proteins: 9694
        Core proteins: 8333
        Plus proteins: 1357
   AMR proteins: 8401
   STRESS proteins: 259
   VIRULENCE proteins: 1034
   PubMed references: 5686
   Point mutations: 1556
   Point mutation reference sequences: 278
   Point mutation organism groups: 
       Acinetobacter_baumannii, Bordetella_pertussis, Burkholderia_cepacia,
       Burkholderia_pseudomallei, Campylobacter, Citrobacter_freundii,
       Clostridioides_difficile, Corynebacterium_diphtheriae, Enterobacter_asburiae,
       Enterobacter_cloacae, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Haemophilus_influenzae, Helicobacter_pylori, Klebsiella_oxytoca,
       Klebsiella_pneumoniae, Neisseria_gonorrhoeae, Neisseria_meningitidis,
       Pseudomonas_aeruginosa, Salmonella, Serratia_marcescens, Staphylococcus_aureus,
       Staphylococcus_epidermidis, Staphylococcus_pseudintermedius, Streptococcus_agalactiae,
       Streptococcus_pneumoniae, Streptococcus_pyogenes, Vibrio_cholerae,
       Vibrio_parahaemolyticus, Vibrio_vulnificus
   HMMs: 780

Updates since release 2026-01-21.1:
   Proteins added: 62
       Core proteins added: 62
       Plus proteins added: 0
   AMR proteins added: 62
   Alleles added: 47
   PubMed references added: 60
   PubMed references removed: 3
   Point mutations added: 40
   Added organism options: Staphylococcus_epidermidis
   Proteins removed: 1
       Core proteins removed: 1
       Plus proteins removed: 0
   Reference Gene Catalog entries changed: 47
   Hierarchy nodes added: 7
   Hierarchy nodes removed: 7
   Hierarchy nodes changed: 6

Added proteins
    core AMR AMR
        ant(3'')-Ic      NG_246019.1 WP_474197946.1     aminoglycoside nucleotidyltransferase ANT(3'')-Ic
        cfr(F)           NG_246020.1 WP_318162114.1     23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(F)
        dfrB13           NG_246021.1 WP_376851895.1     trimethoprim-resistant dihydrofolate reductase DfrB13
        dfrB21           NG_246022.1 WP_474197947.1     trimethoprim-resistant dihydrofolate reductase DfrB21
        blaADC-404       NG_246023.1 WP_474197948.1     extended-spectrum class C beta-lactamase ADC-404
        blaADC-405       NG_246024.1 WP_152951821.1     extended-spectrum class C beta-lactamase ADC-405
        blaADC-406       NG_246025.1 WP_474197949.1     extended-spectrum class C beta-lactamase ADC-406
        blaADC-407       NG_246026.1 WP_474197950.1     extended-spectrum class C beta-lactamase ADC-407
        blaADC-408       NG_246027.1 WP_474197951.1     extended-spectrum class C beta-lactamase ADC-408
        blaAKO-1         NG_246028.1 WP_094762261.1     class C beta-lactamase AKO-1
        blaAXC-10        NG_246029.1 WP_474197952.1     carbapenem-hydrolyzing class A beta-lactamase AXC-10
        blaAXC-11        NG_246030.1 WP_336730445.1     carbapenem-hydrolyzing class A beta-lactamase AXC-11
        blaAXC-12        NG_246031.1 WP_474197953.1     carbapenem-hydrolyzing class A beta-lactamase AXC-12
        blaAXC-13        NG_246032.1 WP_416232628.1     carbapenem-hydrolyzing class A beta-lactamase AXC-13
        blaAXC-9         NG_246033.1 WP_474197954.1     carbapenem-hydrolyzing class A beta-lactamase AXC-9
        blaCHA-1         NG_246034.1 WP_474197955.1     extended-spectrum class A beta-lactamase blaCHA-1
        blaCHC-1         NG_246035.1 WP_474197956.1     extended-spectrum class C beta-lactamase blaCHC-1
        blaCMY-226       NG_246036.1 WP_474197957.1     class C beta-lactamase CMY-226
        blaCTX-M-285     NG_246037.1 WP_474197958.1     extended-spectrum class A beta-lactamase CTX-M-285
        blaKPC-288       NG_246038.1 WP_474197959.1     inhibitor-resistant class A beta-lactamase KPC-288
        blaKPC-289       NG_246039.1 WP_474197960.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-289
        blaKPC-290       NG_246040.1 WP_474197961.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-290
        blaKPC-291       NG_246041.1 WP_462148998.1     class A beta-lactamase KPC-291
        blaKPC-292       NG_246042.1 WP_474197962.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-292
        blaKPC-293       NG_246043.1 WP_463135526.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-293
        blaKPC-294       NG_246044.1 WP_474197963.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-294
        blaKPC-295       NG_246045.1 WP_461928767.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-295
        blaKPC-296       NG_246046.1 WP_463135444.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-296
        blaNDM-97        NG_246047.1 WP_474197964.1     subclass B1 metallo-beta-lactamase NDM-97
        blaOKP-A-23      NG_246048.1 WP_110237651.1     broad-spectrum class A beta-lactamase OKP-A-23
        blaOXA-1433      NG_246049.1 WP_257691531.1     OXA-12 family class D beta-lactamase OXA-1433
        blaOXA-1434      NG_246050.1 WP_185213878.1     class D beta-lactamase OXA-1434
        blaOXA-1435      NG_246051.1 WP_133179849.1     OXA-48 family class D beta-lactamase OXA-1435
        blaOXA-1445      NG_246052.1 WP_474197965.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1445
        blaOXA-1446      NG_246053.1 WP_474197966.1     OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-1446
        blaOXA-1447      NG_246054.1 WP_474197967.1     OXA-10 family class D beta-lactamase OXA-1447
        blaPDC-702       NG_246055.1 WP_474197968.1     class C beta-lactamase PDC-702
        blaPDC-703       NG_246056.1 WP_341860331.1     class C beta-lactamase PDC-703
        blaPDC-704       NG_246057.1 WP_474197969.1     class C beta-lactamase PDC-704
        blaPDC-705       NG_246058.1 WP_474197970.1     class C beta-lactamase PDC-705
        blaPDC-706       NG_246059.1 WP_474197971.1     class C beta-lactamase PDC-706
        blaPDC-707       NG_246060.1 WP_474197972.1     class C beta-lactamase PDC-707
        blaPDC-708       NG_246061.1 WP_474197973.1     class C beta-lactamase PDC-708
        blaPDC-709       NG_246062.1 WP_474197974.1     class C beta-lactamase PDC-709
        blaPDC-710       NG_246063.1 WP_474197975.1     class C beta-lactamase PDC-710
        blaPDC-712       NG_246064.1 WP_039026681.1     class C beta-lactamase PDC-712
        blaPDC-713       NG_246065.1 WP_474197976.1     class C beta-lactamase PDC-713
        mcr-10.6         NG_246066.1 WP_460262468.1     phosphoethanolamine--lipid A transferase MCR-10.6
        mcr-8.6          NG_246067.1 WP_474197977.1     phosphoethanolamine--lipid A transferase MCR-8.6
        qepA11           NG_246068.1 WP_474197978.1     fluoroquinolone efflux MFS transporter QepA11
        qepA12           NG_246069.1 WP_131187005.1     fluoroquinolone efflux MFS transporter QepA12
Added point mutations
    core AMR POINT
        acrR_G28R        Escherichia AMPICILLIN/CHLORAMPHENICOL/FLUOROQUINOLONE/RIFAMPIN/TETRACYCLINE 
        acrR_T5N         Escherichia AMPICILLIN/CHLORAMPHENICOL/FLUOROQUINOLONE/RIFAMPIN/TETRACYCLINE 
        cirA_E388Ter     Escherichia CEFIDEROCOL        
        cirA_S90YfsTer15 Escherichia CEFIDEROCOL        
        mepR_A103V       Staphylococcus_aureus TIGECYCLINE 
        mepR_F27L        Staphylococcus_aureus TIGECYCLINE 
        mepR_G97E        Staphylococcus_aureus TIGECYCLINE 
        mepR_Q18P        Staphylococcus_aureus TIGECYCLINE 
        mexR_C138A       Pseudomonas_aeruginosa CARBAPENEM 
        mexR_C138G       Pseudomonas_aeruginosa CARBAPENEM 
        mexR_P37R        Pseudomonas_aeruginosa CARBAPENEM 
        mexR_Q137H       Pseudomonas_aeruginosa CARBAPENEM 
        mexR_Q137P       Pseudomonas_aeruginosa CARBAPENEM 
        mtrD_K823E       Neisseria_gonorrhoeae AZITHROMYCIN 
        mtrD_K823N       Neisseria_gonorrhoeae AZITHROMYCIN 
        mtrD_R714C       Neisseria_gonorrhoeae AZITHROMYCIN 
        mtrD_R714H       Neisseria_gonorrhoeae AZITHROMYCIN 
        mtrD_R714L       Neisseria_gonorrhoeae AZITHROMYCIN 
        nalC_G71E        Pseudomonas_aeruginosa CARBAPENEM 
        nalC_S209R       Pseudomonas_aeruginosa CARBAPENEM 
        nalD_T158I       Pseudomonas_aeruginosa AZTREONAM/CARBAPENEM/CHLORAMPHENICOL/TETRACYCLINE/VABORBACTAM 
        nfsB_D198Y       Klebsiella_pneumoniae NITROFURANTOIN 
        nfsB_E197Ter     Escherichia NITROFURANTOIN     
        nfsB_W46C        Klebsiella_pneumoniae NITROFURANTOIN 
        oqxR_V130R       Klebsiella_pneumoniae NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE 
        pmrB_E301G       Acinetobacter_baumannii COLISTIN 
        pmrB_L168K       Acinetobacter_baumannii COLISTIN 
        porB1b_GA120del  Neisseria_gonorrhoeae BETA-LACTAM/TETRACYCLINE 
        rpoB_D471E       Staphylococcus_epidermidis RIFAMPIN 
        rpoB_H481C       Staphylococcus_epidermidis RIFAMPIN 
        rpoB_H481N       Staphylococcus_epidermidis RIFAMPIN 
        rpoB_H481Y       Staphylococcus_epidermidis RIFAMPIN 
        rpoB_I527M       Staphylococcus_epidermidis RIFAMPIN 
        rpoB_L466S       Staphylococcus_epidermidis RIFAMPIN 
        rpoB_Q468K       Staphylococcus_epidermidis RIFAMPIN 
        rpoB_Q468L       Staphylococcus_epidermidis RIFAMPIN 
        rpoB_S486F       Staphylococcus_epidermidis RIFAMPIN 
        rpoB_S486Y       Staphylococcus_epidermidis RIFAMPIN 
        rpoB_S529L       Staphylococcus_epidermidis RIFAMPIN 
        soxR_S128del     Escherichia AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE 
Added POINT_DISRUPT genes
    core AMR POINT_DISRUPT
        acrR             Escherichia AMPICILLIN/CHLORAMPHENICOL/FLUOROQUINOLONE/RIFAMPIN/TETRACYCLINE 
        cirA             Escherichia CEFIDEROCOL        
        marR             Escherichia AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE 
        nfsA             Escherichia NITROFURANTOIN     
        nfsB             Escherichia NITROFURANTOIN     
        nfsB             Klebsiella_pneumoniae NITROFURANTOIN 
        ompC             Escherichia CARBAPENEM         
        ompF             Escherichia CARBAPENEM         
        oqxR             Klebsiella_pneumoniae NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE 
        ramR             Salmonella AMPICILLIN/CHLORAMPHENICOL/FLUOROQUINOLONE/RIFAMPIN/TETRACYCLINE 
        uhpT             Escherichia FOSFOMYCIN         
Removed proteins
        blaACT-9         NG_048632.1 WP_013981172.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-9
Changed reference gene catalog records
    mexR AAG03813.1                                 
        product_name:    Pseudomonas aeruginosa MarR family transcriptional repressor MexR -> Pseudomonas aeruginosa effux pump transcriptional repressor MexR 
        subclass:        CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL -> AZTREONAM-AVIBACTAM/CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL/VABORBACTAM 
    mrx(A) AAS13767.1                                
        gene_family:     mrx -> mrx(A)                  
    nalD AAG06962.1                                 
        subclass:        CARBAPENEM/CHLORAMPHENICOL/TETRACYCLINE -> AZTREONAM/CARBAPENEM/CHLORAMPHENICOL/TETRACYCLINE/VABORBACTAM 
    oqxA AAP43109.1                                 
        class:           PHENICOL/QUINOLONE -> NITROFURAN/PHENICOL/QUINOLONE/TETRACYCLINE 
        subclass:        PHENICOL/QUINOLONE -> NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE 
    oqxB AAP43110.2                                 
        class:           PHENICOL/QUINOLONE -> NITROFURAN/PHENICOL/QUINOLONE/TETRACYCLINE 
        subclass:        PHENICOL/QUINOLONE -> NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE 
    tet(38) CAG41879.1                                
        refseq_nucleotide_accession: NG_055984.1 -> <empty>         
        refseq_start:    101 -> <empty>                 
        refseq_stop:     1453 -> <empty>                
        refseq_strand:   + -> <empty>                   
        scope:           core -> plus                   
    tet(38) CAG39166.1                                
        refseq_nucleotide_accession: NG_055983.1 -> <empty>         
        refseq_start:    101 -> <empty>                 
        refseq_stop:     1453 -> <empty>                
        refseq_strand:   + -> <empty>                   
        scope:           core -> plus                   
    tet(38) CCC86880.1                                
        refseq_nucleotide_accession: NG_048136.1 -> <empty>         
        refseq_start:    101 -> <empty>                 
        refseq_stop:     1453 -> <empty>                
        refseq_strand:   + -> <empty>                   
        scope:           core -> plus                   
    tet(38) ABX28186.1                                
        refseq_nucleotide_accession: NG_048134.1 -> <empty>         
        refseq_start:    101 -> <empty>                 
        refseq_stop:     1453 -> <empty>                
        refseq_strand:   + -> <empty>                   
        scope:           core -> plus                   
    tet(38) CBI48032.1                                
        refseq_nucleotide_accession: NG_048135.1 -> <empty>         
        refseq_start:    101 -> <empty>                 
        refseq_stop:     1453 -> <empty>                
        refseq_strand:   + -> <empty>                   
        scope:           core -> plus                   
    acrR_R45C WP_000101737.1                                
        pubmed_reference: <empty> -> 31839709            
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> AMPICILLIN/CHLORAMPHENICOL/FLUOROQUINOLONE/RIFAMPIN/TETRACYCLINE 
    blaIMP-26 ACY01749.1                                
        product_name:    subclass B1 metallo-beta-lactamase IMP-26 -> subclass B1 high level metallo-beta-lactamase IMP-26 
        pubmed_reference: 20463166 -> 20463166,40742163  
    blaOXA-1240 WYF30524.1                                
        product_name:    OXA-48 family class D beta-lactamase OXA-1240 -> OXA-48 family extended-spectrum class D beta-lactamase OXA-1240 
        subclass:        BETA-LACTAM -> CEPHALOSPORIN   
    blaOXA-1399 XZG26185.1                                
        product_name:    OXA-48 family class D beta-lactamase OXA-1399 -> OXA-48 family extended-spectrum class D beta-lactamase OXA-1399 
        subclass:        BETA-LACTAM -> CEPHALOSPORIN   
    mexR_C62Ter WP_003114897.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        CEPHALOSPORIN -> AZTREONAM-AVIBACTAM/CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL/VABORBACTAM 
    mexR_D89N WP_003114897.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        CEPHALOSPORIN -> AZTREONAM-AVIBACTAM/CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL/VABORBACTAM 
    mexR_E109Ter WP_003114897.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        CARBAPENEM/VABORBACTAM -> AZTREONAM-AVIBACTAM/CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL/VABORBACTAM 
    mexR_G101E WP_003114897.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        AZTREONAM/AZTREONAM-AVIBACTAM/CARBAPENEM/VABORBACTAM -> AZTREONAM-AVIBACTAM/CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL/VABORBACTAM 
    mexR_L57P WP_003114897.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        CEPHALOSPORIN -> AZTREONAM-AVIBACTAM/CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL/VABORBACTAM 
    mexR_L57Q WP_003114897.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        CEPHALOSPORIN -> AZTREONAM-AVIBACTAM/CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL/VABORBACTAM 
    mexR_Q106Ter WP_003114897.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        pubmed_reference: 40067045 -> <empty>            
        subclass:        AZTREONAM -> AZTREONAM-AVIBACTAM/CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL/VABORBACTAM 
    mexR_Q31Ter WP_003114897.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        CARBAPENEM -> AZTREONAM-AVIBACTAM/CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL/VABORBACTAM 
    mexR_Q49Ter WP_003114897.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        CARBAPENEM -> AZTREONAM-AVIBACTAM/CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL/VABORBACTAM 
    mexR_Q94Ter WP_003114897.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        CEPHALOSPORIN -> AZTREONAM-AVIBACTAM/CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL/VABORBACTAM 
    mexR_R70Q WP_003114897.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        CEPHALOSPORIN -> AZTREONAM-AVIBACTAM/CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL/VABORBACTAM 
    mexR_R83C WP_003114897.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        CARBAPENEM -> AZTREONAM-AVIBACTAM/CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL/VABORBACTAM 
    mexR_T130P WP_003114897.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        AZTREONAM/AZTREONAM-AVIBACTAM/CARBAPENEM/VABORBACTAM -> AZTREONAM-AVIBACTAM/CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL/VABORBACTAM 
    mexR_Y3Ter WP_003114897.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        AZTREONAM/AZTREONAM-AVIBACTAM/CARBAPENEM/VABORBACTAM -> AZTREONAM-AVIBACTAM/CARBAPENEM/CEPHALOSPORIN/CHLORAMPHENICOL/VABORBACTAM 
    nalD_F198L WP_003092152.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        AZTREONAM -> AZTREONAM/CARBAPENEM/CHLORAMPHENICOL/TETRACYCLINE/VABORBACTAM 
    nalD_G45D WP_003092152.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        CARBAPENEM/VABORBACTAM -> AZTREONAM/CARBAPENEM/CHLORAMPHENICOL/TETRACYCLINE/VABORBACTAM 
    nalD_Q114Ter WP_003092152.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        CARBAPENEM -> AZTREONAM/CARBAPENEM/CHLORAMPHENICOL/TETRACYCLINE/VABORBACTAM 
    nalD_T11N WP_003092152.1                                
        class:           BETA-LACTAM -> MULTIDRUG       
        subclass:        CARBAPENEM/VABORBACTAM -> AZTREONAM/CARBAPENEM/CHLORAMPHENICOL/TETRACYCLINE/VABORBACTAM 
    nfsB_W94Ter WP_000351450.1                                
        pubmed_reference: 34860151 -> 31627025,34860151  
    oqxR_D95E WP_000888203.1                                
        class:           TETRACYCLINE -> NITROFURAN/PHENICOL/QUINOLONE/TETRACYCLINE 
        subclass:        TIGECYCLINE -> NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE 
    oqxR_F6S WP_000888203.1                                
        class:           TETRACYCLINE -> NITROFURAN/PHENICOL/QUINOLONE/TETRACYCLINE 
        subclass:        TIGECYCLINE -> NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE 
    oqxR_Q11L WP_000888203.1                                
        class:           TETRACYCLINE -> NITROFURAN/PHENICOL/QUINOLONE/TETRACYCLINE 
        subclass:        TIGECYCLINE -> NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE 
    oqxR_V102G WP_000888203.1                                
        class:           TETRACYCLINE -> NITROFURAN/PHENICOL/QUINOLONE/TETRACYCLINE 
        subclass:        TIGECYCLINE -> NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE 
    oqxR_V113I WP_000888203.1                                
        class:           TETRACYCLINE -> NITROFURAN/PHENICOL/QUINOLONE/TETRACYCLINE 
        subclass:        TIGECYCLINE -> NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE 
    pmrB_P233T WP_000559382.1                                
        pubmed_reference: 19528270 -> 19528270,32058026  
    ramR_E160D WP_000113609.1                                
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> AMPICILLIN/CHLORAMPHENICOL/FLUOROQUINOLONE/RIFAMPIN/TETRACYCLINE 
    ramR_G25A WP_000113609.1                                
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> AMPICILLIN/CHLORAMPHENICOL/FLUOROQUINOLONE/RIFAMPIN/TETRACYCLINE 
    ramR_M84I WP_000113609.1                                
        pubmed_reference: <empty> -> 18443112            
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> AMPICILLIN/CHLORAMPHENICOL/FLUOROQUINOLONE/RIFAMPIN/TETRACYCLINE 
    ramR_R46P WP_000113609.1                                
        pubmed_reference: <empty> -> 19778917            
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> AMPICILLIN/CHLORAMPHENICOL/FLUOROQUINOLONE/RIFAMPIN/TETRACYCLINE 
    ramR_T18P WP_000113609.1                                
        pubmed_reference: <empty> -> 18443112            
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> AMPICILLIN/CHLORAMPHENICOL/FLUOROQUINOLONE/RIFAMPIN/TETRACYCLINE 
    ramR_T50P WP_000113609.1                                
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> AMPICILLIN/CHLORAMPHENICOL/FLUOROQUINOLONE/RIFAMPIN/TETRACYCLINE 
    ramR_Y59H WP_000113609.1                                
        pubmed_reference: <empty> -> 18443112            
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> AMPICILLIN/CHLORAMPHENICOL/FLUOROQUINOLONE/RIFAMPIN/TETRACYCLINE 
    uhpT_E350Q WP_000879194.1                                
        pubmed_reference: <empty> -> 30543320            

Hierarchy nodes Added
    core AMR AMR
        ant(3'')-Ic      ant(3'')-Ic NF053581.1         aminoglycoside nucleotidyltransferase ANT(3'')-Ic
        blaAKO           blaAPO                         AKO family class C beta-lactamase
        blaCHA           blaCHA NF050809.1              CHA family extended-spectrum class A beta-lactamase
        blaCHC           blaCHC NF050810.1              CHC family extended-spectrum class C beta-lactamase
        cfr(F)           cfr(F)                         23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(F)
        dfrB13           dfrB13                         trimethoprim-resistant dihydrofolate reductase DfrB13
        dfrB21           dfrB21                         trimethoprim-resistant dihydrofolate reductase DfrB21
Hierarchy nodes Removed
    non-reported AMR AMR
        nalD             nalD                           efflux system transcriptional repressor NalD
        nfxB             nfxB                           efflux pump transcriptional repressor NfxB
    non-reported AMR AMR-SUSCEPTIBLE
        AMR-SUSCEPTIBLE                                 Families implicated in adaptive resistance by mutation
        pbp              pbp                            penicillin-binding protein
        pbp1a            pbp1a                          penicillin-binding protein PBP1A
        pbp2b            pbp2b                          penicillin-binding protein PBP2B
        pbp2x            pbp2x                          penicillin-binding protein PBP2X
Changed Hierarchy Nodes
    mleBCA           BCA family alpha/beta fold macrolide esterase 
        hmm_acc:         <empty> -> NF053684.1          
    mleBRB           BRB family alpha/beta fold macrolide esterase 
        hmm_acc:         <empty> -> NF053683.1          
    mleCBF           CBF family alpha/beta fold macrolide esterase 
        hmm_acc:         <empty> -> NF053693.1          
    oqxA             multidrug efflux RND transporter periplasmic adaptor subunit OqxA 
        class:           PHENICOL/QUINOLONE -> NITROFURAN/PHENICOL/QUINOLONE/TETRACYCLINE 
        hmm_acc:         NF000272.1 -> NF000272.2       
        subclass:        PHENICOL/QUINOLONE -> NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE 
    oqxB             multidrug efflux RND transporter permease subunit OqxB 
        class:           PHENICOL/QUINOLONE -> NITROFURAN/PHENICOL/QUINOLONE/TETRACYCLINE 
        subclass:        PHENICOL/QUINOLONE -> NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE 
    tet(38)          tetracycline efflux MFS transporter Tet(38) 
        scope:           core -> plus                   
